Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter
نویسندگان
چکیده
منابع مشابه
Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter
The present study investigated the anti-diabetic activity and potential mechanism of stigmasterol (SMR), which is a kind of phytosterols derived from the edible soybean oil in vitro and in vivo. SMR displayed a mild GLUT4 translocation activity by 1.44-fold in L6 cells. L6 cells were treated with different concentration of SMR, showing significant effects on the enhancing glucose uptake. SMR ad...
متن کاملPhosphorylation of the adipose/muscle-type glucose transporter (GLUT4) and its relationship to glucose transport activity.
The effects of protein phosphorylation and dephosphorylation on glucose transport activity reconstituted from adipocyte membrane fractions and its relationship to the phosphorylation state of the adipose/muscle-type glucose transporter (GLUT4) were studied. In vitro phosphorylation of membranes in the presence of ATP and protein kinase A produced a stimulation of the reconstituted glucose trans...
متن کاملTrafficking, targeting and translocation of the insulin-responsive glucose transporter, GLUT4, in adipocytes.
Insulin-stimulated glucose transport in peripheral tissues: diabetes and the rationale for study Blood glucose homoeostasis is a process that is under very strict metabolic regulation so as to maintain the balance between glucose production by the liver and its utilization by fat and muscle (skeletal and cardiac) ensuring an adequate supply of glucose to the brain and nerve tissues. The uptake ...
متن کاملexpression of glucose transporter 4 (glut4) is increased by cinnamaldehyde in c2c12 mouse muscle cells
background: in diabetes mellitus because of the absence or insufficient sensitivity to insulin, glucose transporter protein in cell membrane, glucose transporter 4, is decreased. glut4 is the major glucose transporter in skeletal muscle and adipose tissue, which is under control of insulin. it remains, however, unclear whether cinnamaldehyde plays a regulatory role(s) or not. objectives: the ob...
متن کاملIntracellular targeting and retention of the glucose transporter GLUT4 by the perinuclear storage compartment involves distinct carboxyl-tail motifs.
The mechanisms by which the insulin-sensitive glucose transporter, GLUT4, is targeted and retained in a storage compartment near to the Golgi complex are poorly understood. Here we report that removal of the carboxyl-terminal acidic Pro(505)AspGluAsnAsp(509) sequence prevents the storage of GLUT4 in the VAMP-2 positive compartment adjacent to the Golgi complex (GSC), and results in its targetin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Food & Nutrition Research
سال: 2017
ISSN: 1654-6628,1654-661X
DOI: 10.1080/16546628.2017.1364117